다비가트란 (Dabigatran)
약물상호작용 효과권고
Amiodarone+12~60%두 개 이상이 해당될 경우 용량을 감량하거나 다른 약제로 변경
Dronedarone+70~100%사용 금기
Quinidine+53%
Verapamil+12~180%용량을 감량하거나 다른 약제로 변경
Ticagrelor+25%
Clarithromycin, Erythromycin+15~20%
Rifampin-66%항응고제 혈중 농도를 감소시키므로 사용 금기
HIV protease inhibitors자료 없음
Intraconazole, Ketoconazole, Voriconazole+140~150%
Digoxin, Diltiazem, Atorvastatin영향 없음
에독사반 (Edoxaban)
약물상호작용 효과권고
Amiodarone+40%
Dronedarone+85%
Quinidine+77%
Verapamil+53%
Clarithromycin, Erythromycin+90%
Rifampin-35%
HIV protease inhibitors자료 없음
Intraconazole, Ketoconazole, Voriconazole+87~95%
Digoxin, Atorvastatin, Naproxen영향 없음
리바록사반 (Rivaroxaban)
약물상호작용 효과권고
Amiodarone영향 적음
DronedaroneModerate effect
Clarithromycin,
Erythromycin+54%
+34%
Rifampin-50%
HIV protease inhibitors+153%
Fluconazole+42%
Intraconazole, Ketoconazole, Voriconazole+160%
Digoxin, Diltiazem, Verapamil, Atorvastatin영향 없음
와파린 (Warfarin)
INR 증가INR 감소
Acetaminophen, Allopurinol, Amiodarone, Amoxicillin, Amoxicillin-clavulanate, Androgens, Azithromycin, Azole antifungals
Cancer drugs, Capecitabine, Cephalosporins, Cholesterol-lowering drugs, Cimetidine, Ciprofloxacin, Clarithromycin
Doxycycline, Duloxetine, Erythromycin
Fenofibrate, Fluconazole, Fluoroquinolones, 5-FU(fluorouracil), Fluoxetine, Fluvastatin, Fluvoxamine, Gemfibrozil, GlucocorticoidsImatinib, Levofloxacin, Lovastatin,
Macrolides, Methylprednisolone, Methyltestosterone, Metronidazole, Miconazole, Moxifloxacin, Norfloxacin
Omeprazole, Oxandrolone, Penicillins (dicloxacillin, nafcillin 제외),Prednisone, Rosuvastatin,
Serotonin reuptake inhibitors, Sertraline, Simvastatin, SitaxentanTamoxifen, Testosterone, Tramadol, Trimethoprim-sulfamethoxazole, Venlafaxine, Voriconazole
Azathioprine, Carbamazepine, Cholestyramine, Dicloxacillin, GriseofulvinNafcillin, Phenobarbital, PhenytoinRifampin, RitonavirSaint John’s wort, SucralfateVitamin K
CAPs